Clinical Trials Information

Welcome to the Judy Nicholson Kidney Cancer Foundation Information site on Clinical Trials! On the webpage below, you will find videos on how you can find Clinical Trials, as well as the type of information you should know about them before you enroll. 

If you have any additional questions about Clinical Trials, please do not hesitate to reach out to us via email at: clinicaltrials@jnfkidneycancer.org.

Download PDF Tutorials here:
Cancer Details Checklist
How do I find a Clinical Trial for Kidney Cancer
Questions to Ask Your Doctor about Clinical Trials as an Option


Finding a Clinical Trial:
Resources and Trial Finders

1.        Cancer.gov offers a comprehensive trial search engine which allows you to search kidney cancer for trials close to your home

 https://www.cancer.gov/about-cancer/treatment/clinical-trials/search

Cancer.gov offers Telephone assistance.  These services are free.  Trained trial counselors are available  to help you find appropriate trials 1-800-4-CANCER

2.       IKCC, one of our partner organizations,  offers a really unique trial finder that focuses on iImmuno-Oncology (I-O) clinical trials with information in a patient friendly format

http://www.10forio.info/discovering-clinical-trials-for-kidney-cancer

3.       IKCC also offers a comprehensive trial search engine.  They add some information to make it a little easier for patients to find and understand the information

http://ikcc.org/clinical-trials-database/

 


RCC Clinical Trials in Florida

  1. Interleukin-2 and Pembrolizumab for Metastatic Kidney Cancer
    ClinicalTrials.gov ID#: NCT02964078
    Phase: 2
    Location: H. Lee Moffitt Cancer Center & Research Institute
    Tampa, FL 33612
    Contact Info: Cortlin Croft (813) 745-7559 / Cortlin.Croft@moffitt.org
    Principal Investigator: Mayer Fishman, M.D., Ph.D. 
    Type of Trial: Advanced RCC - Prior Treatment
     
  2. Study of HBI-8000 with Nivolumab in Melanoma, Renal Cell Carcinoma & Non-Small Cell Lung Cancer
    ClinicalTrials.gov ID#: NCT02718066
    Phase: 1B/2
    Location: Hem-Onc Associates of Treasure Coast,
    Port St. Lucie, FL 34952
    Contact Info: Dmitri Kharkevitch, MD, PhD | (858) 798-8800 | dkharkevitch@huyabio.com
    Principal Investigator: Nikhil I Khushalani, MDH.
    Lee Moffitt Cancer Center & Research Institute, Tampa, FL
    Related Information: Experimental: HBI-8000 in combination with Nivolumab
    Type of Trial: Advanced RCC - Prior Treatment
     
  3. A Randomized Phase 2 Trial of Axitinib and TRC105 Versus Axitinib Alone in Patients With Advanced or Metastatic Renal Cell Carcinoma
    ClinicalTrials.gov ID#: NCT01806064
    Phase: 1 and 2
    Location: University of Florida, Gainesville, FL
    University of Miami, Miami, FL
    Moffitt Cancer Center, Tampa, FL
    Contact Info: ClinicalTrials@traconpharma.com
    Type of Trial: Advanced RCC - Prior PD-1 & PD-L1 Allowed
     
  4. Pazopanib Hydrochloride in Treating Patients with Metastatic Kidney Cancer
    ClinicalTrials.gov ID#: NCT01767636
    Phase: 2
    Location: Mayo Clinic in Florida Recruiting
    Jacksonville, FL 32224-9980
    Contact Info: Clinical Trials Referral Office: (855) 776-0015
    Principal Investigator: Winston Tan, MD. 
    Related Information: Non-Clear Cell RCC. Only one prior treatment allowed.
    Type of Trial: Advanced RCC Prior Treatment
     
  5. A Phase 2 Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects with Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced Disease
    ClinicalTrials.gov ID#: NCT01767636
    Phase: 2
    Location: Mayo Clinic in Florida Recruiting
    Jacksonville, FL 32224-9980
    Contact Info: Eisai Medical Services (888) 274-2378
    esi_medinfo@eisai.com
    Related Information: Non Clear Cell
    Type of Trial: Advanced RCC - No Prior Treatment
     
  6. A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy
    ClinicalTrials.gov ID#: NCT03024996
    Phase: 3
    Location: University of Miami, School of Med; Hem/Onc
    Miami, FL 33136 | Moffitt Cancer Center, Tampa, FL 33612
    Contact Info: Reference Study ID#: WO39210
    (888) 662-6728 (US & Canada) 
    Related Information: Nephrectomy Required
    Type of Trial: Adjuvant
     
  7. A Study of Avelumab With Axitinib Versus Sunitinib In Advanced RCC (JAVELIN: Renal 101)
    ClinicalTrials.gov ID#: NCT02684006
    Phase: 3
    Location: Moffitt Cancer Center & Research Institute
    Tampa, FL United States
    Contact: PhizerCT.gov Call Center: (800) 718-1021
    Type of Trial: Advanced RCC-No Prior Treatment
     
  8. Trial of X4P-001 in Patients With Advanced Renal Cell Carcinoma
    ClinicalTrials.gov ID#: NCT02667886
    Phase: 1 and 2
    Location: Jacksonville, FL United States
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 & PD-L1 Allowed.
     
  9. A Study to Evaluate the Safety of Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Cancer
    ClinicalTrials.gov ID#: NCT02982954
    Phase: 4
    Location: Florida Cancer Specialists S. | Fort Myers, FL 33901
    Orlando Health, Orlando, FL 32806
    Contact Info: Clinical.Trials@bms.com
    Principal Investigator: Bristol-Myers Squibb
    Type of Trial: Advanced RCC - No prior treatment
     
  10. Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Suitinib Alone as Treatment of Advanced Renal Cell Carcinoma
    ClinicalTrials.gov ID#: NCT02811861
    Phase: 3
    Location: University of Miami | Miami, FL United States
    Contact Info: Eisai Medical Info (888) 274-2378 | esi_medinfo@eisai.com
    Type of Trial: Advanced RCC - No Prior Treatment
     
  11. An Investigational Immuno-Therapy Safety and Efficacy Study of Multiple Administration Regimens for Nivolumab Plus Ipilimumab in Subjects with Renal Cell Carcinoma
    ClinicalTrials.gov ID#: NCT03029780
    Phase: 2
    Location: Cancer Specialists of North Florida
    Jacksonville, FL 32256
    Contact Information: Bijoy Telivala, Site 0010 | (904) 538-4488
    Related Information: No prior checkpoint inhibitors
    Type of Trial: Advanced RCC - Prior Treatment
     
  12. Study of Pembrolizumab (MK-3475) Monotherapy in Locally Advanced/Metastatic Renal Cell Carcinoma (MK-3475-427/KEYNOTE-427)
    ClinicalTrials.gov ID#: NCT02853344
    Phase: 2
    Location: Call for information (Investigational Site 8007) Miami, Florida, 33140
    Contact Info: (888) 577-8839
    Principal Investigator: Merck Sharp & Dohme Corp.
    Type of Trial: Advanced RCC - No Prior Treatment
     
  13. Cabozantinib-S-Malate, Crizotinib, Volitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
    ClinicalTrials.gov ID#: NCT02761057
    Phase: 2
    Location: Mount Sinai Medical Center, Miami Beach, FL United States 33140
    Contact Info: Michael A. Schwartz | (305) 674-2625 | info@msccop.com
    Principal Investigator: Michael A. Schwartz
    Related Information: Papillary RCC
    Type of Trial: Advanced RCC - Prior Treatment
     
  14. Sunitinib Malate With or Without Gemcitabine Hydrochloride in Treating Patients With Advanced Kidney Cancer That Cannot Be Removed By Surgery
    ClinicalTrials.gov ID# NCT01164228
    Phase: 2
    Location: Mayo Clinic - Jacksonville, FL 32224
    Contact Info: Clinical Trials Office - All Mayo Clinic Locations
    (507) 538-7623
    Principal Investigator: Naomi S. Balzer-Haas, MD | Abramson Cancer Center, University of Pennsylvania
    Related Information: Advanced Renal Cell Carcinoma with Sarcomatoid features
    Type of Trial: Advanced RCC - No Prior Treatment
     
  15. A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Subjects With Solid Tumors
    ClinicalTrials.gov ID# NCT02576665
    Phase: 1
    Location: University of Miami - Sylvester Comprehensive Cancer Center, Miami, FL 33136
    Contact Information: Jamie Merchan, MD (305) 243-1287
    JMerchan2@med.miami.edu | Tamara Leon Aliz (305) 243-0865
    txl351@med.miami.edu
    Principal Investigator: Jaime R. Merchan, MDUniversity of Miami
    Related Information: Should enroll prior to nephrectomy
    Type of Trial: Neoadjuvant
     
  16. A Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors
    ClinicalTrials.gov ID#: NCT02599324
    Phase: 1 & 2
    Location: Cancer Specialists, LLC, Dept of Clinical Research Recruiting
    Jacksonville, Florida, United States 32256
    Contact Information: Jenni Bachhofer (904) 363-7462 ext: 1179
    Jenni.Bachhofer@csnf.us | Judy Bulacan (904) 264-6201 Judy.Bulacan@csnf.us
    Principal Investigator: Mehdi M Moezi, MD
    Type of Trial: Advanced RCC - Prior Treatment
     
  17. Study of the Glutaminase Inhibitor CB-839 in Solid Tumors
    ClinicalTrials.gov ID#: NCT02071862
    Phase: 1
    Location: Florida Cancer Specialists, Sarasota, FL 34232
    Contact Info: (941) 377-9993
    Principal Investigator: Manish R. Patel, MD
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 and PD-L1 allowed.
     
  18. Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
    ClinicalTrials.gov ID#: NCT02568267
    Phase: 2
    Location: H. Lee Moffitt Cancer Center and Research Institute, Inc. Tampa, FL 33612
    Contact Info: Ignyta Inc., (844) 782-7875 STARTRKtrials@ignyta.com
    Principal Investigator: Christine Chung, MD
    Related Information: Metastatic solid tumor that harbors an NTRK1/2/3, ROS1, or ALK gene rearrangement
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  19. Safety Study of MGA271 in Refractory Cancer
    ClinicalTrials.gov ID#: NCT01391143
    Phase: 1
    Location: Moffitt Cancer Center Recruiting, Tampa, FL 33612
    Contact Information: Allison Richards, MS (813) 745-8352 allison.richards@moffitt.org
    Principal Investigator: Jeffrey Weber, M.D., PhD
    Related Information: Histologically or cytologically confirmed renal cell carcinoma that overexpresses B7-H3
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  20. Study Of OX40 Agonist PF-04518600 Alone And In Combination With 4-1BB Agonist PF-05082566
    ClinicalTrials.gov ID# NCT02315066
    Phase: 1
    Location: H. Lee Moffitt Cancer Center and Research Institute, Inc., Tampa, FL 33612
    Contact Info: Pfizer CT.gov (800) 718-1021
    Related Information: Solid tumor with limited RCC access
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed.
     
  21. Pembrolizumab Combined With Itacitinib (INCB039110) and/or Pembrolizumab Combined With INCB050465 in Advanced Solid Tumors
    ClinicalTrials.gov ID#: NCT02646748
    Phase: 1
    Location: Port St. Lucie, FL
    Contact Information: Incyte Corporation Call Center (855) 463-3463
    Related Information: Solid Tumor with Limited RCC Access
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  22. A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Renal Impairment
    ClinicalTrials.gov ID#: NCT02301117
    Phase: 1
    Location: Gainesville, FL 32610
    Contact Info: Robert Winkler, MD
    (855) 598-8259 | rwinkler@taihooncology.com
    Principal Investigator: Robert Winkler, MD (609) 750-5300
    Related Information: Solid Tumor for patients with renal impairment
    Type of Trial: Advanced RCC Prior Treatment with PD-1 PD-L1 Allowed.
     
  23. A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) in Subjects With Selected Cancers (INCB 24360-202 / MK-3475-037 / KEYNOTE-037/ ECHO-202)
    ClinicalTrials.gov ID#: NCT02178722
    Phase: 1/2
    Location: Miami, FL
    Contact Information: Incyte Call Center (855) 463-3463
    Type of Trial: Advanced RCC - Prior Treatment
     
  24. A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma
    ClinicalTrials.gov ID#: NCT02601950
    Phase: 2
    Location: Mayo Clinic - Jacksonville Recruiting
    Jacksonville, FL 32224
    Contact Information: Rebecca Souliere | souliere.rebecca@mayo.edu
    Principal Investigator: Steven Attia, MD
    Related Information: Rhabdoid and Renal Medullary Kidney Cancer
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  25. NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma
    ClinicalTrials.gov ID#: NCT02465060
    Phase: 2
    Location: Mayo Clinic - Jacksonville Recruiting, Jacksonville, FL 32224
    Contact Info: Alan H. Bryce (855) 776-0015
    Principal Investigator: Alan H. Bryce
    Related Information: Solid Tumor with Limited RCC Access
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed.
     
  26. A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
    ClinicalTrials.gov ID#: NCT02335918
    Phase: 1/2
    Location: Mount Sinai Medical Center Recruiting
    Miami Beach, FL 33140
    Contact Info: Jose Lutzky, MD | jose.lutzky@msmc.com
    Principal Investigator: Jose Lutzky, MD
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  27. Study of FPA008 in Combination With Nivolumab in Patients With Selected Advanced Cancers
    ClinicalTrials.gov ID#: NCT02526017
    Phase: 1
    Location: H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612
    Contact Information: Medical Lead FPA008003@fiveprime.com
    Principal Investigator: Heloisa Soares, MD, PhD
    Related Information: Solid Tumor with Limited RCC Access
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed
     
  28. Pembrolizumab and Ziv-aflibercept in Treating Patients With Advanced Solid Tumors
    Clinical Trials.gov ID#: NCT02298959
    Phase: 1
    Location: H. Lee Moffitt Cancer Center & Research Institute
    Tampa, FL 33612
    Contact Information: Mayer N. Fishman (800) 456-7121
    CancerAnswers@moffitt.org
    Principal Investigator: Mayer N. Fishman
    Type of Trial: Advanced RCC - Prior Treatment
     
  29. Phase I/II Study of IMMU-132 in Patients With Epithelial Cancers
    ClinicalTrials.gov ID#: NCT01631552
    Phase: 1/2
    Location: MD Anderson Cancer Center Orlando
    (UF Health Cancer Center) Orlando, FL
    Contact Information: Georgina Hollenbach, RN
    Georgina.Hollenbach@orlandohealth.com
    Principal Investigator: Rebecca Moroose, MD
    Related Information: Solid Tumor with Limited RCC Access
    Type of Trial: Advanced RCC - Prior Treatment
     
  30. Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
    ClinicalTrials.gov ID#: NCT02867592
    Phase: 2
    Location: Florida Hospital Orlando Recruiting
    Orlando, FL 32803
    Contact Information: Fouad M. Hajjar (407) 303-2090 FH.Cancer.Research@flhosp.org
    Principal Investigator: Fouad M. Hajjar
    Related Information: Pediatric, Kidney Cancer including Wilms
    Type of Trial: Advanced RCC - Prior Treatment with PD-1 PD-L1 Allowed.